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ABSTRACT
Intermittent fasting is an eating pattern that cycles between periods of fasting and eating. It has recently gained much popularity as an effective method to reduce weight. It is now practiced by many people. The danger of getting chronic diseases has increased due to changes in modern lives and excessive food consumption. More than pharmacological therapies, a change in lifestyle, such as dietary changes and increased physical activity, is the initial therapeutic approach to preventing chronic disorders. Although it has been postulated by literatures that intermittent fasting tends to have fewer risks and side effects, some other studies have also associated it with alterations in the normal body physiology. Therefore, this study aims to determine the variations in some haematological, inflammatory and fibrinogen to platelet ratio coagulative indices in intermittent fasting. A total of 120 blood sample comprising of 60 test samples and 60 control samples were employed for this research. 8millilitres of blood sample was collected twice for both test and controls samples and analyzed for haematological parameters, random and fasting blood sugar levels and fibrinogen concentration using ERMA HAEMATOLOGY autoanalyzer PCE-210N, Accuchek glucometer and ELISA method respectively. Neutrophil lymphocyte ratio, Monocyte lymphocyte ratio ratio, Platelet lymphocyte ratio and Fibrinogen platelet ratio were estimated using ratio formulas. Data obtained was analysed by the Statistical Package for Social Science (SPSS) software. The results showed that the total white blood cell count (TWBC) and Neutrophils were significantly higher (5.53 ± 1.34; 39.98 ± 7.80)in the fasting state when compared to the non-fasting state (4.22 ± 1.95, 27.20 ± 11.54) (p<0.05). Monocytes and Lymphocytes were significantly lower in the fasting phase (8.42 ± 1.95, 51.60 ± 7.89) when compared to the non-fasting phase (12.42 ± 3.26, 58.04 ± 15.41) (p<0.05). Neutrophil lymphocyte ratio was significantly lower in the fasting phase (0.46 ± 0.32) when compared to the non-fasting phase (0.83 ± 0.37) while Monocyte lymphocyte ratio was significantly (p=0.040) higher in the fasting phase (0.20 ± 0.06) when compared to the non-fasting phase (0.17 ± 0.05) (P<0.05). Fibrinogen-platelet ratio (FPR) was significantly (p<0.001) lower in the fasting phase (0.02 ± 0.01) when compared to the non-fasting phase (0.03 ± 0.02). Glucose level was significantly lower in the fasting phase when compared to the non-fasting phase (91.50 ± 3.58, 75.81 ±1.75) In conclusion, the results from this study indicate that intermittent fasting significantly affected some haematological, inflammatory and haemorrheological parameters.
