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ABSTRACT
Elaeis guineensis is one of the plants proven to have economical and health benefits, however, consumption of adulterated palm oil have resulted in varieties of diseases owing to the damage of some internal organs such as kidney. Only few studies exist for evaluations of the toxicological effects of adulterated palm oil on biochemical parameters. This study was therefore undertaken to evaluate the effect of adulterated palm oil on the activity of kidney enzyme and biomarker of albino rats. A total of (48) wistar rats divided into 8 groups of 6 rats each and were treated for 14 days. At the end of the experiment, animals were sacrificed and dissected, the kidney was harvested for analysis. Biochemical indices of the body weight, kidney weight, enzyme and biomarker were evaluated. The body weight showed a significant change at p <0.05 when compared with the initial weight (week 0). The weight of the kidney was observed, however, there was no significant increase when compared with group 1 and 2, control and crude palm oil respectively. Group 5 showed a significant increase (p <0.05) when compared with group 1 and 2. The kidney enzyme (Glutathione peroxidase), showed no significant change when compared with group 1 and 2, however, the biomarker (Malondialdehyde), showed a significant increase at p <0.05 when compared with the group 1 and 2. The results of this study suggest that adulterated palm oil with Sudan dyes have toxic properties that may be effective in the management of kidney enzymes and biomarkers.
