ABSTRACT

Medicinal herbs are used by the majority of people worldwide to treat a range of illnesses. African sausage tree, or Kigelia africana (Bignoniaceae), is a traditional medicinal plant used to treat a wide range of illnesses. Many medicinal qualities of the plant are thought to exist, such as antibacterial, anticancer, anti-inflammatory, antioxidant, and so forth. This study outlines the pharmacological, phytochemical, and membrane-stabilizing characteristics of Kigelia africana. The goal of this experiment is to evaluate the fruit Kigelia africana's anti-inflammatory qualities. Through the use of heat-induced hemolysis and the stabilisation of human red blood cell membrane lysing, the in-vitro anti-inflammatory efficacy of Kigelia africana (Lam.) Benth. extract and its fractions were examined. Methanol plant extract (MPE) and its fraction (EF) demonstrated phytochemically favourable results for the presence of numerous phytochemical components, including flavonoids, heart glycosides, tannins, saponins, and others. Concentration-dependent membrane stability in the extract and different fractions was equivalent to that of the standard (aspirin).In comparison to aspirin, which had a positive effect with the highest percentage mean inhibition of 27.068% at the same concentration, the methanol extract, DCM, and n-hexane fraction of Kigelia africana fruit demonstrated positive results for stabilization of HRBC membrane by heat-induced hemolysis with highest percentage mean inhibition of 27.275%, 36.217%, and 23.552% at 1000μg/ml concentration (Table 3.1.1). With a percentage mean inhibition of 26.168% at 100μg/ml, the ethylacetate fraction had the highest level (Table 3.1.1).In vitro, Kigelia africana methanol extract had encouraging