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ABSTRACT
This present study was carried out to investigate the influence of magnesium adaptation on membrane potential stabilization in acute myocardial infarction and oxidative stress. A total of 16 adult New Zealand rabbits of both sexes with average weight between 1.7-2.8kg were randomly divided into two experimental groups of 8 rabbits each. Group one was fed with normal rabbit pellets and water ad libitum. Group 2 was fed with normal rabbit pellets and high magnesium (4.8mM)/day for 16 weeks (Magnesium adapted rabbits). At the end of the 4months, each group was divided into 2 sub-groups (N=4) control and test (myocardial infarction (MI) + oxidative stress (OS) induction through subcutaneous administration of adrenaline hydrochloride at a single dose of 1mg/kg/ on two consecutive days with an interval of 24 hours between applications and at the end of the 2nd day, oxidative stress was induced in a single dose of 1ml/kg/body weight. Twenty-four hours after the induction of oxidative stress, each animal was anesthetized using chloroform vapour and 5ml of blood sample collected via cardiac puncture for analyses. The results showed that there was a significant decrease in creatinine kinase for magnesium adapted rabbits (MAR) when compared to the control group (NMAR). Troponin I decreased in MAR and even more in MAR induced with MI and OS when compared with NMAR induced with MI and OS. The study also showed that SOD activity, an antioxidant, increased in MAR compared to the control group (NMAR). Magnesium adaptation increased Mg ATPase activity in MI and OS in MAR when compared with NMAR. Also, Na/K ATPase activity increased significantly in MAR when compared with NMAR, but significantly decreased in MAR induced with MI and OS when compared with NMAR. P<0.05. In conclusion, the result of the present study suggests that magnesium adaptation may be beneficial in membrane potential stabilization effect in myocardial infarction and oxidative stress in rabbits.
