You have no items in your shopping cart.
ABSTRACT
Myocardial infarction (MI) is a pathogenic event of heart attack which is due to formation of plaques in the interior walls of the arteries resulting in reduced blood flow to the heart as a result of lack of oxygen supply. Growing evidence supports an increased CVD risk and red blood cells dysfunction with low dietary magnesium intake. This study was aimed at investigating the influence of magnesium adaptation on blood parameters in acute myocardial infarction and oxidative stress in rabbits. A total of 16 adult New Zealand rabbits of both sexes with average weight between 1.7-2.8kg were commercially obtained and randomly grouped into two (2) groups of 8 rabbits each. Group one was fed with normal rabbit pellets and water ad libitum. Group 2 was fed with normal rabbit pellets and high magnesium (4.8mM)/day for 16 weeks (Magnesium adapted rabbits). At the end of the 16th weeks, each group was divided into 2 sub-groups (N=4) control and test (myocardial infarction (MI) + oxidative stress (OS) induction) through subcutaneous administration of adrenaline hydrochloride at a single dose of 1mg/kg/ of adrenaline on two consecutive days with an interval of 24 hours between applications and at the end of the 2nd day, oxidative stress was induced with carbon tetrachloride (CCL4) in a single dose of 1ml/kg/bw. The results showed that magnesium supplementation significantly decreased antioxidant activity (MDA)in magnesium adapted rapid when compared with none magnesium adapted rabbit while SOD was significantly increased in magnesium adapted rabbits compared to none magnesium adapted rabbit, both MDA, SOD and Troponin I showed a significant decrease in the magnesium adapted rabbit when induced with myocardial infarction and oxidative stress compared to none magnesium adapted rabbit with induced myocardial infarction and oxidative stress. In blood parameters, RBC showed no significant difference in magnesium adapted rabbit when compared to magnesium adapted rabbit induced with MI and OS. WBC levels were enhanced in magnesium adapted rabbit when compared to magnesium adapted rabbit induced with MI and OS. In platelets there was a significant decrease in magnesium adapted rabbit induced with MI and OS when compared to none magnesium adapted rabbit. In PCV and HGB, there was a significant increase in magnesium adapted rabbit induced with MI and OS when compared to none magnesium adapted rabbit. In conclusion, this work has shown that magnesium adaptation may offer beneficial haematological health indices in acute myocardial infarction and oxidative stress condition in rabbits.
