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ABSTRACT
Datura stramonium, a plant known for its medicinal and toxic properties, is widely used in traditional medicine. However, its toxic effects remain a concern. This study evaluates the impact of Datura stramonium leaf extract on Drosophila melanogaster, focusing on survival rates and metabolic markers such as urea and creatinine levels. The study aims to investigate the dose-dependent toxic effects of Datura stramonium leaf extract by analyzing survival patterns and changes in urea and creatinine concentrations in Drosophila melanogaster. Adult flies were exposed to varying concentrations (2000 mg/kg, 4000 mg/kg, and 8000 mg/kg) of Datura stramonium leaf extract. Survival rates were monitored over 21 days, and biochemical assays were used to measure urea and creatinine levels. Survival analysis revealed a clear doseresponse relationship. The 8000 mg/kg dose resulted in 100% mortality by day 21, while the 4000 mg/kg dose caused 79.87% mortality. The 2000 mg/kg dose exhibited moderate toxicity, with 48.87% survival by day 17. Urea and creatinine levels showed no statistically significant differences across treatment groups compared to the control (p > 0.05). The results highlight the dose-dependent toxic effects of Datura stramonium leaf extract on Drosophila melanogaster. While survival rates were significantly affected, the lack of changes in urea and creatinine suggests that its toxicity may involve pathways beyond nitrogen metabolism. This study underscores the toxic potential of Datura stramonium and the need for further research to understand its mechanisms and establish safe usage guidelines.
