The effects aqueous extract of Coconut water on the liver of Rats treated with lead acetate

SUMMARY

Lead toxicity is directly related its absorption and retention in some tissues such as liver, kidney and gastrointestinal tracts (Rhman et al, 2011).Following oral administration, the most common effects induced by short-term exposure to lead acetate are reduced growth, alterations in organ weights or histopathology (particularly of the kidney, testes, liver, and intestine), and effects on the immune system (Borzelleca et al., 1989). The liver is a major site for xenobiotic metabolism and is thus prone to oxidative damage by toxicants, pro-drugs or procarcinogens. The highest concentrations of cadmium in the human body accumulate in the kidney (particularly the cortex) and the liver, although the metal can be detected in virtually all tissues (Elinder, 1985).