ABSTRACT
Various plants have been examined for their varying levels of toxicity. The investigation into toxicity involves administering extracts from these plants at various doses over a specific duration. Among these plants, Uraria picta, a member of the leguminous family, is a key component of India's widely used Ayurvedic medicine. The objective of this research was to assess how Uraria picta impacts the hematopoietic system in albino Wister rats with MSGinduced toxicity. The Uraria picta leaves were subjected to a drying process, then ground, and finally soaked in methanol for a duration of three days. Next, the methanol extract underwent a freeze-drying process. The animals were divided into eight groups, each consisting of five rats. In Group 1, rats were given 800mg/kg of MSG. Group 2 served as the control group. Group 3 received 100mg/kg of the extract, while Group 4 received 250mg/kg of the extract. Notably, Group 4 was the one exposed to both MSG and Uraria picta, while the remaining groups were administered a combination of Uraria picta and Letoderris extract. The impact of these given doses of the plant revealed notable outcomes. There was a substantial decrease in the white blood cell count in the rats given doses of 100mg/kg, 250mg/kg, and 800mg/kg of MSG. Conversely, there was a significant rise in red blood cell count among the rats administered with 800mg/kg of MSG and 250mg/kg, while there was no substantial increase in those given 100mg/kg. A noteworthy rise in hemoglobin levels was observed in the rats subjected to doses of 800mg/kg of MSG and 250mg/kg of Uraria picta. However, there was no substantial increase in hemoglobin levels in the group receiving 100mg/kg of Uraria picta. Additionally, there was a significant increase in the mean corpuscular hemoglobin concentration in the rats given 100mg/kg, 250mg/kg, and 800mg/kg of MSG in combination with Uraria picta. There was a notable rise in the mean corpuscular value in the rats that received 800mg/kg of MSG, 100mg/kg of Uraria picta, and 250mg/kg of Uraria picta. Furthermore, there was a significant increase in mean corpuscular hemoglobin levels in the rats given 800mg/kg of MSG, 100mg/kg of Uraria picta, and 250mg/kg of Uraria picta when compared to the control group. The experiment demonstrated that the plant extract effectively altered the concentration of the component within the hematopoietic system, both increasing and decreasing it when compared to the control group.
