THE EFFECT OF THE DICHLOROMETHANE FRACTION OF URARIA PICTA

ABSTRACT

The research explores how the dichloromethane (DCM) fraction from Uraria picta affects estrogen, progesterone, and aromatase levels. It emphasizes the importance of understanding hormonal regulation in health and disease. Estrogen, progesterone and aromatase play crucial roles in reproductive health, bone metabolism, cardiovascular function, and hormonesensitive cancers. The study aims to uncover the impact of Uraria picta’s DCM fraction on these hormones, potentially leading to new therapies. The methodology describes the experimental setup, including dosages for control, monosodium glutamate (MSG) (800 mg/kg), and MSG/UP (100 mg/kg) groups. It measures estradiol, progesterone, and aromatase levels to assess Uraria picta’s effects. The discussion interprets the results. MSG (800 mg/kg) increased estradiol and aromatase but decreased progesterone compared to controls. In contrast, MSG/UP (100 mg/kg) decreased estradiol but increased progesterone, potentially inhibiting aromatase. These findings reveal complex interactions between treatments and hormone levels, suggesting Uraria picta’s therapeutic potential for hormone-related conditions. In summary, the study sheds light on Uraria picta’s hormonal effects. Changes in estrogen, progesterone, and aromatase levels suggest its potential as a natural remedy for hormonerelated disorders. Further research is needed to understand its mechanisms and clinical applications.