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ABSTRACT
According to recent statistics, the prevalence of diabetes mellitus has increased dramatically over the last decade, and it may now be called a developing epidemic with a proposed estimated effect on 693 million people aged 18 to 99 which accounts for 9.9% of the global population by 2040. Currently, the main and widely used treatment for diabetes is the use of insulin and hypoglycaemic drugs, but these compounds also have many adverse side effects which have led to extensive studies into the use of medicinal plants which are thought to have fewer side effects. Tetrapleura tetraptera is one of the African plants shown to have antidiabetic effects and this study probes its potential in vivo effect on anti-inflammatory genes (Interleukin-6(IL-6), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Intercellular Adhesion Molecule (ICAM-1), Tumor Necrosis Factor-α (TNF- α) and Kidney Injury Molecule-1 (KIM-1)), body weight and organ body weight ratio and compare these effects with results obtained from metformin (a standard hypoglycemic drug) both in streptozotocin induced diabetic male Wistar rats.
