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ABSTRACT
Overnight fasting which is a form of Intermittent fasting (IF) is a dietary approach where individuals consume regular meals during specific intervals and then undergo extended periods with minimal or no energy intake for time periods that can range from 12hours to several days, on recurring basis which has same health benefits as overnight fasting. Inflammatory ratios, which are used in medical diagnostics are calculated by analyzing the level or ratios of certain blood markers, including neutrophils, fibrinogen, platelets and others, to assess the presence and severity of inflammation in the body. The aim of this study is to evaluate the effect of intermittent fasting on some inflammatory ratios and serum bilirubin concentration. Sixty (60) individuals including male and female within the age of 18-30 years were recruited for this study. This study was conducted in the University of Benin environment. About 10mls of blood samples were collected with minimal trauma via the cubital fossa using a sterile disposable syringe and needle. 5ml of blood were emptied into EDTA bottles for hematological analysis and 5ml of whole blood dispensed into lithium heparin bottle, spun and the supernatant dispensed into plain containers for bilirubin estimation. The results showed no significant difference in bilirubin, platelets, platelets-lymphocyte ratio during the fasting phase when compared to non-fasting phase but there was a significant increase in NLR in fasting phase compared to non-fasting phase coupled with a significant decrease in MLR in fasting individual. In Conclusion, this study has shown that intermittent fasting has a significant effect on some inflammatory ratios and no significant effect on bilirubin concentration.
