You have no items in your shopping cart.
ABSTRACT
Regular and high intake of fructose is a factor contributing to the development of oxidative stress, insulin resistance, hyperglycemia and hypertension which are directly associated with metabolic syndrome and cardiovascular disease. The aim of this study was to evaluate the therapeutic effect of high dose Paxherbal bitters on the glucose metabolism and oxidative stress in albino rats fed high-fructose diet. Twenty albino rats randomly divided into four groups of five rats each, with the average weight of each group being about 175g. The rats were fed ad-libitum with the feed and clean tap water during the entire 8 weeks course of this study. A basal diet of modified standard pelleted mash, was given daily to rats of control group, while the high-fructose diet was given to the remaining three groups. A combination of the drugs Lisinopril and atorvastatin was also administered daily to the group 3 rats, while the high dose (1,100mg/kg of the rat’s body weight) of the Paxherbal bitters was also administered to the rats, their daily feed consumption, food efficiency, the relative organ weight of the liver, kidney and heart and aorta, their fasting blood sugar and antioxidant status was also determined. The data was analysed using paired sample student’s T test and Duncan’s multiple test ANOVA of the SPSS v.24. A p value of less than 0.05 (P<0.05) was accepted as statistically significant. The results of this study reveals that Paxherbal bitters prevented the increase in relative organ weight of the rats and were as effective as Lisinopril and atorvastatin in preventing the features characteristic of diet induced insulin resistance and oxidative stress. Paxherbasl bitters also prevented the development of oxidative stress. These finding affirm Paxherbal bitters can be a good therapeutic supplement in the prevention of diet induced insulin resistance and oxidative stress.
