THE EFFECT OF MONTELUKAST AND HYDROCORTISONE ON SOME LIVER FUNCTION TEST ON ASTHMA-INDUCED WISTAR RATS

ABSTRACT

Asthma is a chronic inflammatory disease affecting over 300 million people worldwide. The number of total cases has since been stable, mortality has been slower to decline since the discovery of suitable and effective medications. But this medications has been under clinical survey to determine their side effect on some organs of the body. Our main focus is the effect of the treatment (hydrocortisone and montelukast) on liver; the liver engage in the breakdown and detoxification of drugs thus, the need to carry out liver function test (LFT)  to determine the effect of those treatment on the liver by measuring some liver enzymes activities and bilirubin concentration. Methodology: 25 albino wistar rat was divided into control and test groups,  the test was further divided into four(4) groups. The test groups was sensitized and induced with asthma using ovalbumin (100ug/kg I.P) for 0-14 days and was challenged Ova 0.5% w/v (dissolve in 100mg/ml aluminium hydroxide (2mg/kg) three days a week for four weeks with a medel family Nebulizer. Asthma induction was confirmed with evidence of nuetrophilia and eosonoplia in all test groups when compared to control group, after which they were treated with montelukast (3mg/kg), hydrocortisone (2mg/kg) and both montelukast and hydrocortisone (2mg/kg and 3mg/kg) respectively, on the 28th days, blood sample was collected and analysed using selectra pro machine. Conclusion: After the analysis was done, it was proven that within the period of treatment, the drugs pose no serious effect on the liver.