You have no items in your shopping cart.
This study was carried out to evaluate the effect of methanolic extract of Dialium guineense stem bark on liver antioxidant status of diabetic rats. 20 adult male Wistar rats weighing 150 to 180g were randomly assigned to five (5) groups of four (4) rats each. Groups 2-5 were induced intraperitoneally with alloxan, while group 1 rats were non-diabetic and thus, served as normal control. Group served as diabetic control as they were not administered any portion of the extract. Group 3 rats were treated with a standard anti-diabetic drug; metformin and this served as positive control. The observation groups (Group 4 and 5) received 200mg/kg body weight and 100mg/kg body weight, of methanol extract orally for 14 days. The result revealed no significant difference (p>0.05) in the activity of SOD, total protein and Glutathione peroxidase (GPx) in the liver of diabetic rats administered methanolic extract of Dialium guineense at doses 200mg/kgbw and 100mg/kgbwwhen compared to the control. However, the concentration of MDA was significantly lower (p<0.05) in the observation group treated with 200mg/kgbw and 100mg/kgbw doses of the extract when compared to the control. The same trend was seen in liver catalase but only in the group administered 100mg/kgbwt of the extract, which could mean that the extracts may have potentiated the antioxidant system of the rats. Plasma catalase concentration however increased significantly (p<0.05) in both of the extract-treated observation group. A significant increase in the concentration of Glutathione was demonstrated in only rats administered 200mg/kgbwt of the extract when compared to the diabetic control. The observed antioxidant effect may be due to the presence of important phytochemicals in the extract of this medicinal plant.
