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ABSTRACT
High-fructose diet usage has reached an all-time high with a 2,000% increase in products consumed in a Western diet, the increase in the consumption high fructose has led to various metabolic diseases like dyslipidaemia and hyper triglyceridemia.
The aim of this study was to evaluate the therapeutic effect of medium dose Paxherbal bitters on the lipid and uric acid metabolism in albino rats fed high-fructose diet. Twenty albino rats randomly divided into four groups of five rats each, with the average weight of each group being about 175g. The rats were fed ad-libitum with the feed and clean tap water during the entire 8 weeks course of this study. A basal diet of modified standard pelleted mash, was given daily to rats of control group, while the high-fructose diet was given to the remaining three groups. A combination of the drugs Lisinopril and atorvastatin was also administered daily to the group 3 rats, while the Medium dose (1,100mg/kg of the rat’s body weight) of the Paxherbal bitters was also administered to the rats, their daily feed consumption, food efficiency, the relative organ weight of the liver, kidney and heart and aorta, their fasting blood sugar and antioxidant status was also determined. The data was analyzed using paired sample student’s T test and Duncan’s multiple test ANOVA of the SPSS v.24. A p value of less than 0.05 (P<0.05) was accepted as statistically significant. The results of this study reveals that Paxherbal bitters prevented the increase in relative organ weight of the rats and were as effective as Lisinopril and atorvastatin in preventing the features characteristic of diet induced dylipidemia and hyperuricedemia. Paxherbal bitters also prevented the development of increased uric acid level, dyslipidemia and hyper triacyglyceridemia. These finding affirm Paxherbal bitters can be a good therapeutic supplement in the prevention of dyslipidemia, triacyglyceridemia and increased uric acid level.
