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ABSTRACT
Arthritis is characterized by chronic inflammation and oxidative stress. Some studies have suggested a link between high triglyceride levels in the blood (hypertriglyceridemia) and certain types of arthritis, including Rheumatoid arthritis. Kigelia africana has been used traditionally for decades to treat illnesses associated with inflammation. The total antioxidant capacity of methanol and flavonoid-rich extracts of Kigelia africana fruit was determined using standard method. Results revealed that the methanol extract had a significantly higher (p<0.05) total antioxidants activity than the flavonoid rich extract. This revealed the extracts are sources of natural antioxidants. The effect of methanol and flavonoid-rich extracts of Kigelia africana on serum triglycerides level of Sprague dawley rats was evaluated using standard method. Sixty rats weighing between 100-230g were separated into ten (10) groups thus; normal group, positive control group, negative control group, groups treated with reference drugs (Dexamethasone and Diclofenac-Na), group treated with quercetin, and groups treated with different doses of methanol and flavonoid-rich extracts of Kigelia africana. Triglycerides level were determined via a triglyceride colorimetric assay. Results showed that the treated groups had a decrease in serum level of triglycerides than the negative control. This may be due to the total antioxidant capacity of the extracts. This may justify the use of Kigelia africana by traditional herbal practitioners in the treatment of diseases.
