ABSTRACT
The aim of this project study is to investigate the effects of garlic on the ovary of female wistar rats 25 female wistar rats were purchased from the animal holdings of the department of Anatomy, school of Basic Medical Sciences, University of Benin, Benin City. Body weight changed and ovary weight index were determined.
They were divided into five groups of five rats each. Group A served as the control group, Group B was threated with 250mg/kg body weight of the extract, Group C was treated with 10ml/kg of cadmium, Group D was treated with 10mg/kg cadmium and 250mg/kg garlic extract. Group E was treated with 10mg/kg cadmium and 500mg/kg garlic extract. All groups were given feed and water. This experiment spanned for after which the ovaries were excised, weighed and fixed in formaldehyde.
There was statistically significant decrease (P < 0.05) of estradiol in groups C, D and E when compared to the control. There was no statistical significant difference (P > 0.05) in ovarian weights across the groups.
There was no statistical significant change (P < 0.05) in gonadosomatic index across the groups.
H and E staining revealed the effect of garnic administration on the stroma of the ovaries. H and E staining also revealed cadmium administration caused haemorrhagic effect on the stroma of the ovaries.
