THE EFFECT OF ETHANOL EXTRACT OF C.DEPENDENS ON LIVER FUNCTION TEST PARAMETERS (ALT, AST, AND ALP) IN CCL4 INDUCED TOXICITY

ABSTRACT

Liver damage caused by xenobiotics is a significant health concern, and the search for natural compounds with hepatoprotective properties is ongoing. This study investigates the potential of the ethanol extract of C. dependens as a therapeutic agent against CCl4-induced hepatotoxicity. This study hypothesized that C. dependens extract could mitigate liver damage by reducing levels of ALT, AST, and ALP. The research questions aimed to elucidate the baseline levels of these enzymes, their changes following CCl4 administration, and the impact of C. dependens extract. Additionally, we explored dose-dependent effects and compared C. dependens with a standard hepatoprotective agent. The results revealed that C. dependens extract exhibited promising hepatoprotective effects, significantly reducing ALT and ALP levels, suggesting liver damage mitigation. While AST reductions were not as pronounced as with silymarin, the results remained noteworthy. Dose-dependent effects were observed, implying that higher dosages may yield more robust outcomes, although caution is needed to avoid potential side effects. In conclusion, this study highlights the hepatoprotective potential of C. dependens extract in mitigating CCl4-induced liver damage. Its ability to reduce ALT, ALP, and AST levels underscores its potential to protect liver tissue from toxic insults. However, further investigation is required to determine optimal dosages and species-specific effects. This research contributes to the growing body of evidence supporting C. dependens as a natural hepatoprotective agent, with potential therapeutic applications in liver disease prevention and treatment.