THE EFFECT OF CELLGEVITY ON LIPID PROFILE IN MALE WISTAR RATS FED A HIGH FRUCTOSE DIET

ABSTRACT

High fructose intake is suspected to be causally linked to dyslipidemia and metabolic syndrome disorders; the aim of this study was to assess the therapeutic effect of Cellgevity on lipid profile in male Wistar rats fed a high fructose diet. Twenty (20) male Wistar rats with an average weight of 200g each were divided into four groups of five. The rats were fed ad-libitum during the entire duration of the experiment. A basal diet of standard pelleted grower’s mash was given to the control group (group 1), while other groups received 60% fructose diet and 10% fructose water. Treatments with Atorvastatin and Cellgevity for groups 3 and 4 respectively were administered using an oro-gastric gavage. The weekly weight, daily feed consumed, feed efficiency and the relative organ weight of the heart, liver and kidney were determined using standard methods. A comprehensive biochemical assessment of lipid profile parameters was performed and the data were analyzed using the one-way analysis of variance (ANOVA), followed by Turkey’s test of significance. The high fructose diet fed rats had an elevated triglyceride, total cholesterol, LDL, VLDL and AIP levels but a decreased HDL level. Furthermore, Atorvastatin improved HDL levels and caused a decrease in triglyceride, total cholesterol, LDL, VLDL and AIP levels. However, Cellgevity mitigates high fructose diet induced dyslipidemia by causing reduction in triglyceride, total cholesterol, LDL, VLDL and AIP levels as well an increase in HDL level. The results present promising evidence for the therapeutic potentials of Cellgevity against high fructose diet induced dyslipidemia.