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ABSTRACT
This work was done to determine the curative effect of the plant, Musa paradisiaca on gastric ulceration induced by aspirin. Twenty-four wister albino rats were divided into six groups of four rats. All the groups were induced with 210 mg/Kg aspirin with the exception of the normal control group (group 1). While group 2 rats were untreated, rats in group 3, 4 and 5 were administered 200 mg/kg, 400 mg/kg, and 800 mg/kg ethanol extract of Musa paradisiaca respectively for five days. Group 6 was administered 5mg/Kg b.wt of omeprazole (standard drug). Elemental analysis was also carried out on the ethanol extract of Musa paradisiaca. The red blood cell indices were taken at conclusion of therapy period and properly assessed. Results showed no significant change in the red blood cell indices. The mean ulcer index of the untreated group was significantly higher than the other groups treated with the standard drug and the ethanol plantain extract. A very high level of potassium was present in the extract and a very low concentration. The group that received ethanol plantain extract had the highest ulcer inhibition percentage compared to the group treated with the standard drug showing that the plant, Musa paradisiaca has an enormous potential in the curation of ulcer and does not affect red blood cell indices. Its curative effect on ulcer is determined by the amount of dosage taken at a particular period of time.
