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ABSTRACT
This study presents a comparative analysis of baseline lipid profiles between Sprague Dawley (SD) and Wistar rats, two commonly used strains in biomedical research. Lipid profiles, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides, were measured in serum samples obtained from female rats of both strains. Results indicate significant differences in baseline lipid levels between the two strains, with SD rats exhibiting higher levels of total cholesterol and LDL-C compared to Wistar rats. Conversely, Wistar rats showed higher HDL-C levels than SD rats. These findings suggest strainspecific variations in lipid metabolism, which may have implications for experimental design and interpretation in preclinical studies. Understanding baseline lipid profiles in different rat strains is crucial for establishing appropriate control groups and interpreting experimental outcomes accurately in biomedical research.
