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ABSTRACT
Spondias mombin is a fructiferous tree having habitat in Nigeria, Brazil and several other tropical forests in the world. This plant is readily common around us in the south west of Nigeria and is commonly used in folk Medicine. This study was carried out to evaluate the anti-diabetic and anti-inflammatory effect of ethanol extract of the leaves of Spondias mombin in streptozotocin induced diabetic rats. 24 male albino wistar rats were randomly divided into 4 groups (6 rats each) 1 to 4. Group 1 served as the normal control, group 2, 3 and 4 were induced with Streptozotocin (STZ). Group 4 animals were treated with ethanol extracts (200mg/Kg b.w), administered daily for 28 days. At the end of the study duration based on the statistics obtained, it was observed that there was a gradual reduction of blood glucose in the Spondias mombin treated rats, together with a significant reduction in the expression of inflammatory markers IL-1β, and TNF-α, when compared to the diabetic control. Results of this study also showed that the oral administration of ethanol extract of Spondias mombin causes a significant increase in the body weights of diabetic rats
