SYNTHESIS OF QUINOLINE-N-OXIDE 4-THIOACETIC ACID

ABSTRACT

Quinoline or benzopyridine is a nitrogen containing heterocyclic compound possessing antimalarial, anti-bacterial, antifungal, anti-inflammatory, and analgesic activity, quite a few of which are under clinical investigation to combat potentially lethal diseases/disorders. A number of compounds containing quinoline nucleus are agents of choice for the treatment of various ailments, particularly cancer and malaria. In this study, a heterocyclic derivative based on quinoline containing thioacetic acid is described by a five step reaction. Here, quinoline-N-oxide, 4- nitroquinolone-N-Oxide, 4-chloroquinoline-N-oxide, quinoline-N-oxide-4thiol were successful prepared. Furthermore, the latter was coupled with chloroacetic acid (ClCH2COOH) in the presence of sodium chloride (NaOH) to obtain quinoline-N-oxide-4-thioacetic acid with %yield; 2.86, m.p.(°C) 96-98, Rf 0.83, appearance white crystal.