ABSTRACT
The Quinoline scaffold gained attention in modern days being an important chemical moiety in
the identification designing and Synthesis of novel potent derivatives. This study extensively
shine the light on the synthesis and critical significant insight on the quinoline derivatives
possessing diverse biological activities. A Quinoline analog, N-ethyl-8-methoxy-5-quinoline
sulphonamide was synthesized and characterized physically. In this study, the quinoline analog
was prepared first by the reaction of 8-hydroxyquinoline and methyl iodide in acetone and
potassium carbonate. Followed by the preparation of 8-methoxy-5-quinolineSulfonylchloride
from 8-Methoxyquinoline, dichloromethane, iron(iii)chloride and chlorosulfonic acid. Then the
reaction of 8- methoxy-5-quinoline sulfonylchloride with ethylamine to give N-ethyl-8-methoxy-
5quinolinesulfonamide. The physical properties of the intermediate and the target were
determined as shown.The result indicates that the target compound was a white crystalline
solid which was soluble in ethanol.The Synthesis of the N-ethyl-8-methoxy-5-
quinolinesulfonamide is straight and efficient involving three steps which is methoxylation,
sulphonation and amination. The purity of the target compound was detected by a single spot
on TLC plate.
