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ABSTRACT
Numerous quinoline derivatives play a big role in the progress of organic synthesis and applications to medicinal chemistry. Recently, researchers have synthesized hybrid quinoline scaffolds with compounds containing other heterocyclic compounds using different procedures. For example, through transitional metal catalysed or metal-free reactions, ultrasound irradiation, or multicomponent one-pot synthesis, modified named reactions can be instigated to synthesize various noble and effective quinoline derivatives. Until now the synthesis and modification of a quinoline scaffold and investigations to improve its biological and pharmaceutical activities have been continually developing. Nowadays researchers are focused not only on the synthesis of quinoline and its derivatives but also on developing and designing eco-friendly reaction procedures. Quinoline and its derivatives have exhibited a potentially wide range of applications to treat various kinds of human infections, such as bacterial infections, cancer, malaria and fungal infections.
