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ABSTRACT
Hydroxyapatite (HAp) is the main inorganic constituent of bone material and is widely used in various biomedical applications due to its excellent bioactivity and biocompatibility. In nature, nanostructure hydroxyapatite is the main constituent present in hard body tissues. Hence, nanotechnology can be exploited to synthesize nanoparticles of hydroxyapatite that has similar properties of natural hydroxyapatite. Sustainable methods to mass-produce synthetic hydroxyapatite nanoparticles are being advanced to meet the augmented demand for these materials and to further improve the progress made in hard tissue engineering, especially for orthopedic and dental applications. Thus there is need to proffer a suitable method to control the morphology and size of nanoparticles of hydroxyapatite. Nanocrystalline powders of HAp were prepared from calcium nitrate, Ca(NO3)2 and diammonium hydrogen phosphate, (NH4)2HPO4 in the presence of sorbic acid as a surface modifier via simple precipitation approach. The addition of sorbic acid as surface modifier and the variation of the pH of the reaction solution are the most significant variables in altering the HAp structure and morphology.
