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ABSTRACT
Hydroxyapatite (HAp) is the main inorganic constituent of bone material and applicable in various biomedical applications due to its excellent bioactivity and biocompatibility. In nature, nanostructure hydroxyapatite is the main constituent present in hard body tissues. Hence, nanotechnology can be exploited to synthesize nanoparticles of hydroxyapatite that has similar properties of natural hydroxyapatite. Sustainable methods to mass-produce synthetic hydroxyapatite nanoparticles are being advanced to meet the demand for these materials and to further improve the progress made in hard tissue engineering, especially for orthopedic and dental applications. Thus there is need to proffer a suitable method to control the morphology and size of nanoparticles of hydroxyapatite. The addition of hippuric acid as surface modifier in this experiment and the variation of the pH of the reaction solution are the most significant variables in altering the HAp structure and morphology. The FTIR spectrum indicated functional group present in HAp. The SEM monographs demonstrated the effect of hippuric acid on the surface of HAp and pH on controlling the morphology as well as reducing the size of nanoparticles. At pH 9, the HAp nanoparticles showed the lesser and better particle size and spherical nature.
