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Abstract
Antibiotics are generally chemotherapeutic agents which are toxic to invading organisms but mild to their host. Complexation is very relevant in Pharmacy as a means of modifying the pharmachological, toxicological and physio-chemical properties of drugs. In this study, Iron (III) complexes of ciprofloxacin, amoxicillin, and ampicillin were synthesized through systematic choice of solvents and reaction condition. The aqueous solubility profile of the complex were determined and the relative thermal and acid stability were determined spectrophotometrically.
Antimicrobial studies were also carried out on the complexes. The complexes showed improved aqueous solubility when compared to those of the corresponding parents drugs (ligands). The results generally showed that the complexes have enhanced thermal and acid stabilities with respect to the parent drugs ciprofloxacin complex showed improved antibacterial potency against Escherichia coli, pseudomonas aeruginosa, klebsellia pneumonia streptococcus aureus and salmoneola typhi when compared with that of the parent drugs. Fe 3+ complexes of amoxicillin and ampicillin showed decreased antibacterial potency against streptococcus aureus when compared with the parent drug. The approximate molecular weight of the complexes were determined by measurement of boiling point elevation (ebullioseopic method) and Job’s method of continuous variation and this gave a 1:2 metal to ligand stoichiometry for ciprofloxacin and 1:1 for amoxicillin and ampicillin respectively. The structures of the complexes were proposed based on stoichiometry assuming a coordination number of 6.
