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ABSTRACT
The fact that medicinal plants are used around the world to cure a variety of illnesses is due to their pharmacologically significant phytoconstituents, which are thought to be natural and hence have low to no toxicity. The inappropriate use of these plants (excessive or wrong dose) may cause toxicity in major metabolic processes, tissues or organs. This study aims to determine the toxic effect of hydro-ethanol polyherbal (Hibiscus sabdariffa Linn., Zingiber officinale Roscoe, Cinnamomum verum, and Syzygium aromaticum) extract in Wistar rats. A 70:30% hydro-ethanol solution was used for extraction. A total of 25 male Wistar rats weighing 100±20g were used for the 21-day study. The rats were divided into five groups, the control group was administered distilled water, while the other groups were administered 250mg/kgHE, 500mg/kgHE, 1000mg/kgHE and 2000mg/kgHE dosage of the hydro-ethanol polyherbal formulation extract. The rats were then sacrificed and the blood was collected for lipid profiling. The results revealed that the extract may possess dyslipidemic properties at 250mg/kg, 500mg/kg and 2000mg/kg dosage but the 1000mg/kg dose may possess antilipidemic effect. Thus, usage of the formulation for a long-term period at these doses should be done with caution.
