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ABSTRACT
As a result of the many phytochemicals found in medicinal plants, they have the ability to prevent, manage, and cure diseases. The use of A. wilkesiana in herbal medicines dates back to the early years, and it exhibits a number of different pharmacological traits. The aim of the current study was to assess the toxicity of A. wilkesiana . Previous research has suggested that this plant may be taken as a dietary supplement. Subacute toxicity study was carried out for eight weeks . Seven groups of four healthy rats each were formed out of a total of twenty eight healthy rats, and they were adequately fed every day. Group 1 was the control and was subjected to regular food and water only, while Groups 2, 3, and 4 received 1000, 1500, and 2000 mg/Kg bwt of methanol extract respectively and groups 5, 6 and 7 received 1000, 1500, and 2000 mg/kg bwt of aqeuous extract resprctively. Animals were subjected to an overnight fast after the duration of the investigation and euthanized. The blood sample was collected from the abdominal aorta and analyzed for renal indices. The kidney of the animals were harvested and homogenized while the blood was collected and centrifuged to obtain the serum and both were subjected to biochemical assays. I checked for creatinine and urea levels. Results obtained from this study showed that administration of either methanol or aqeuous extract had no significant impact on urea and creatinine levels (p > 0.05). Hence extract of A. wilkesiana did not show any nephrotoxicity at the highest dose.
