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Abstract
Cadmium is a hepatotoxic toxicant that occurs ubiquitously in the environment while Persea americana seed, recognized for its rich content of phytochemicals such as polyphenolic compounds, which exhibit potent antioxidant properties. This study aims to investigate the potential ameliorative effect of Persea americana on selected antioxidant parameters in the liver of cadmium-exposed rats... A total of 25 male albino rats (Wistar strain) were divided into five groups: a control group, cadmium only group, 500 mg/kg bwt Persea americana only (PAE500) group, cadmium and 250 mg/kg bwt. of P. americana (Cd+PAE250) and group administered with cadmium and 500 mg/kg bwt P. americana (Cd+PAE500). Cadmium was administered subcutaneously only once while P. americana was administered daily by gavage for 14 days. Malondialdehyde (MDA) level and selected antioxidant enzymes; Superoxide Dismutase (SOD) and Catalase (CAT) activities as well as histopathology were determined in the liver. Cadmium significantly reduced SOD and CAT level and increased MDA level. P. americana seed extract in (Cd+PAE250, (Cd+PAE500). Histopathology showed necrosis in cadmium exposed rats. Treatment with 250 mg/kg bwt. has no effect against necrosis. This study shows that the liver was effectively protected by P. americana at 500 mg/kg bwt..
