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ABSTRACT
Emergence of multi- drug resistant bacteria has rekindled interest on plant derived compounds as substitute for synthetically produced antimicrobial agents. This study determined the antimicrobial activity of ethyl acetate extract of Chrysophyllum albidum fruit mesocarps, proximate analysis of nutritional as well as phytochmical constituents and chemical composition of the preferred fruit mesocarps. Minimum inhibitory concentration (MIC) and Minimum Microbicidal Concentration (MMC) were determined. Proximate nutritional analysis and photochemical studies were carried out. The extract inhibited the growth of all test bacteria with different inhibition zone diameters (IZD) of 19.50 mm - 13.00 mm, but showed no activity to clinical fungal isolates used at 500 mg/ml concentration of extract. Phytochemical analysis revealed the number of secondary metabolites with known antimicrobial properties (steroids, flavoroids, glycosides, terpemoids, tannins, phenolics, saponins) while alkaloids and anthraguinones were not detected. Proximate analysis have shown that the fruit mesocarp contain appreciable quantity of moisture, ash, lipid, crude fibre, crude protein and carbohydrate. Gas - chromatographyMass spectrometry identified various phytocomponents. The observed antimicrobial activities of this plant may be due to the presence of steroid (phytosterol), glycoside (cardiac glycosides), terprenoids, tannins, phenolics and saponins. The presence of high amount of nutritional constitutions in the fruits mesocarp of Chrysophyllum albidum as shown in our study may be indicative of the nutritive potential of the fruit mesocarp.
