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ABSTRACT
Cyperus esculentus is known to possess phytochemicals like flavonoids and phenolic compounds which have antioxidant properties and can scavenge free radicals thus reducing oxidative stress caused by Reactive Oxygen Species (ROS). Investigating its ameliorative properties in the epididymis of cadmium induced rats could offer useful insights in its therapeutic potentials. The objective of this study was to determine the effect of cadmium toxicity in epididymal antioxidant enzymes like Superoxide Dismutase (SOD), Catalase and Malondialdehyde (MDA) and to establish the ameliorative effect or otherwise of aqueous extract of Cyperus esculentus on the epididymis of cadmium exposed rats. A total of 35 male albino wistar rats were selected into five groups. The groups were control group, cadmium only group, Cyperus esculentus only group, cadmium and 2ml/kg concentration of Cyperus esculentus and group administered with cadmium and 4ml/kg concentration of Cyperus esculentus. Superoxidase dismutase activity was determined by the method of Misra and Fridovich. Catalase determined by the method of Cohen et al and Malondialdehyde activities were determined by the method of buerge and aust.(1978).x stress The results showcase the ability of tiger nut extract to ameliorate cadmium induced oxidative stress. SOD levels demonstrated a significant increase, indicating enhanced antioxidant defense mechanisms. MDA levels, a marker of lipid peroxidation was notably reduced. Furthermore, CAT was elevated underscoring the antioxidant potential of tiger nuts.
