ABSTRACT

This study investigated the antimicrobial profile on clinical nasal isolate and antioxidant properties of ethanol and aqueous extract of H umbellata seed. The Gas chromatography-Mass Spectrometry (GCMS) method  was characterized of the active ingredients present in H umbellata. The ethanol extract had the highest coefficient of determination (R² = 0.98) followed by the aqueous extract R² = 0.99. the ethanol extract of H umbellata is rich in several phytochemical compounds. The antimicrobial properties was tested on clinical nasal isolate using broth dilution methods. The antimicrobial effects of H umbellata extract were most evident at higher concentrations, effectively suppressing growth in some bacteria. The antioxidant properties of the H umbellata seed was tested using 2,2-phenyl-1-picrylhydrazl (DPPH) radical scavenging assay method. The aqueous extract revealed 1-butanol, 3-methyl, sulfide as ethanol extract in different proportion. To assess the safety and effectiveness of H umbellata extracts in treating nasal infections, more study should concentrate on separating the active ingredients and carrying out preclinical and clinical trials.