You have no items in your shopping cart.
In this study, the changes observed in the haematological parameters were grouped based on whether the Day 0 days mean values were maintained when compared with other days.The haematocrit reduced significantly (P< 0.05) from day 0 to day 28 during the entire storage period in agreement with the work done by Adias et al., 2012. This gradual fall in haematocrit during storage was due to the depletion of red cell ATP. Previous studies had linked ATP depletion to loss of membrane function, reduced cell viability and rising levels of potassium and free haemoglobin in the plasma of stored whole blood (Hess, 2006; Adias et al., 2012).
The mean white blood cells decrease significantly (p<0.05)from day 0 to day 28 compared to day 0 , this agrees with Hess 2006; Adais et al., 2012 that these change may be as a result of deterioration in granules due to effect of loss of individual cell degeneration of aged cells (Cohl et al., 1981). The clinical implications collectively known as the red blood cell storage lesion which is in part related to bioreactive substances released by leucocytes in the medium such as histamine, lipids and cytokines which may exert direct effects on recipients. Many others are related to metabolic activity like membrane vesiculation, decrease in cell size and increase in cell density, alteration of cytoskeleton, enzymatic desilylation and phosphatidylserine exposure.
