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ABSTRACT
Potassium is the most abundant intracellular cation which is present in all body tissues and is required for normal cell function because of its role in maintaining the intracellular fluid volume and transmembrane electrochemical gradient. This study was aimed atassessing the effects of potassium adaptation on some hematological indices in rats. Sixteen adult wister rats of both sexes were used in this study and were divided into 2 groups. The control group Acomprised of 8 healthy wister rats (4males and 4females) and test group Bcomprise of 8 potassium adapted wister rats (4males and 4females). The rats in the test group were given 0.75% KCl solution orally for 5 weeks in place of tap water. Blood samples of 5ml were collected and then analysed on full blood count which included: HCT, Hb concentration, Red cells indices, WBC count, differential WBC, and platelet counts. The haematological indices were assessed using the haematology auto-analyzer. Results showed that some of the haematological indices such as HCT, RBC, WBC, monocytes, lymphocytes, granulocytes and platelet counts had no significant differences after potassium adaptation (P>0.05, respectively), while MCV, HB, MCH and MCHC showed a significantly lower values (P<0.05, respectively). In conclusion, a significant increase in the MCV coupled with concomitant decrease in hemoglobin concentration, MCH and MCHC could be associated changes with potassium adaptation.
