SINGLE NUCLEOTIDE POLYMORPHISM OF OVIDUCTAL GLYCOPROTEIN 1 (OVGP 1) GENE IN RABBITS

ABSTRACT

The purpose of this study was to examine the single nucleotide polymorphism in the rabbit oviductal glyco protein 1 gene, or OVGP 1. The rabbit holds significant value as a meat source and is now considered essential in certain countries.A potent technique for identifying particular loci accountable for genetic variation associated with desirable productive features in animal species is the oviductal glycoprotein 1 gene approach. The oviduct secretory epithelium is primarily responsible for the synthesis and release of the high molecular weight, oestrogen-dependent glycoprotein known as oviductal glycoprotein 1 gene (OVGP1). According to the research, OVGP1 benefits sperm, ovum penetration, fertilization and the early stages of embryonic development in mammals. Many of these OVGP1s, according to sequence analysis, have low levels of identity (37–63%) and high levels of similarity (50–75%) in the C-terminal area of the protein core, and high levels of identity (77–84%) and similarity (86–90%) in the N-terminal region. The results demonstrated that OVGP1 binds to sperm and influences sperm survival, motility, and acrosome reaction in a positive way. Additionally, OVGP1 may be involved in the early stages of embryonic development. The study emphasizes how crucial it is to comprehend genetic markers for marker-assisted selection to improve rabbit reproductive function, especially in OVGP1.