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ABSTRACT
It has been shown that certain plants and their constituents are potentially toxic. This research assesses the toxicological properties of Mojeaga herbal remedy on female reproductive system. The effect of Mojeaga herbal remedy was tested using standard procedure on female reproductive hormonal assay, lipid profile, body/organ mass indexes and female in-vivo anti-oxidant study. Graded doses of the product at 150, 300, 600 mg/kg were administered orally. The results showed a small significant rise in serum estrogen and progesterone concentrations relative to the control, an increase in luteinizing hormone levels and follicle stimulating hormone concentrations. Triglyceride (TAG), Total Cholesterol (TC) and Low Density Lipoproteins (LDL) concentrations were maintained within normal ranges by the Mojeaga herbal remedy at graded doses, with a small rise in High Density Lipoproteins (HDL) concentration compared to the control. When compared to the control the female treated organ of the product had a better architectural structure. Therefore, since Malondialdehyde (MDA) levels are maintained at normal values in the female treated groups relative to the control, Mojeaga herbal remedy did not cause the overproduction of free radicals to the systems since the level of oxidants was regulated, possibly due to the existence of natural antioxidants. This findings confirmed that there was no toxic effect of the Mojeaga herbal remedy on the female reproductive system.
