RENOPROTECTIVE PROPERTIES OF THE ROOT AQUEOUS EXTRACT OF THE PLANT ON CHOLESTEROL INDUCED RENOCHOLESTEROL IN WISTAR RAT

ABSTRACT

Obesity is commonly characterized by an excessive accumulation of body fat due to a prolonged imbalance between energy intake and energy expenditure. Obesity does not only increase the risk of developing kidney disease but also exacerbates the progression of existing kidney conditions. This study aims at evaluating the renoprotective properties of the aqueous extract of Irvingia gabonensis roots in cholesterol-induced lipidemia in Wistar rats. The plants were collected, authenticated and processed into aqueous extracts. Twenty-five wistar rats of both sexes were used for the study, with cholesterol induced obesity. The animals were administered at graded doses (25, 50, and 100 mg/kg). Negative control received cholesterol alone, positive control received (Atorvastatin 10 mg/kg) while the treated groups received graded doses (25, 50, and 100 mg/kg) of the aqueous extract orally for 21 days. Their stool was observed daily to check for fat deposits. The results obtained from this study showed that the root aqueous extract elicited an inhibitory effect in obesity and kidney indices in rats across the graded doses of extract when compared with the control groups. These findings showed the promising effect of the root aqueous extract as renoprotective properties. This validated the previous folklore findings and give room for further research.