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ABSTRACT
Asthma, a chronic inflammatory disease, is characterized by oxidative stress, which plays a significant role in its pathogenesis. Reduced Glutathione (GSH) and Malondialdehyde (MDA) are critical markers of oxidative stress and antioxidant defense. This study investigates the impact of Synclisia Scabrida meirs on GSH and MDA levels in the heart tissue of a Wistar rat model of Ovalbumin-induced asthma. Fifteen Wistar rats were divided into four groups: control, asthma-induced, asthma-induced treated with Synclisia Scabrida meirs, and healthy. Asthma was induced using Ovalbumin. GSH and MDA levels in heart tissue were measured using standard biochemical assays. Data were analyzed using ANOVA and post-hoc tests to determine statistical significance. The study revealed significant differences in GSH concentrations among the treatment groups. Rats treated with Synclisia Scabrida meirs showed higher GSH levels compared to the untreated asthma-induced group, indicating enhanced antioxidant defense. However, MDA levels did not show significant differences among the groups, although a trend towards reduced oxidative stress was observed in treated groups. Synclisia Scabrida meirs appears to enhance antioxidant defense in the heart tissue of asthmatic rats by increasing GSH levels. While the impact on MDA levels was not statistically significant, the findings suggest potential therapeutic benefits of Synclisia Scabrida meirs in managing oxidative stress associated with asthma. Further research with larger sample sizes and additional biomarkers is recommended to validate these findings.
