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ABSTRACT
Lead (Pb) exposure poses a significant risk to the hippocampus, a critical brain region responsible for memory and emotional regulation. Such exposure can lead to memory deficits, cognitive impairments, and emotional instability. Plant-based antioxidants hold promise as potential therapeutic agents against lead-induced hippocampal damage. These antioxidants safeguard cellular integrity by neutralizing harmful reactive oxygen species and promote cellular repair, offering hope for mitigating the cognitive and emotional consequences of lead exposure. Cucumis sativus is a plant with many properties and its antioxidant properties are well established. Accordingly, this study is aimed at investigating the potential neuroprotective activity of Cucumis sativus fruit extract on Lead-induced neurotoxicity in the Hippocampus of adult Wistar rats. In this study, twenty-four (24) Wistar rats were randomly divided into three groups of eight (8) rats each. Group A rats served as the control group and were administered 1ml of distilled water. Group B rats were administered 100 mg/kg body weight of Lead acetate only. Group C rats were administered 250 mg/Kg body weight of Cucumis sativus and 100 mg/kg body weight of Lead acetate after an hour. The administration was done orally for twenty-eight (28) days.
