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ABSTRACT
Environmental pollution increases the level of hazardous chemicals in the environment with severe effects. Numerous chemicals have been associated with increased production of unregulated free radicals and reactive oxygen species (ROS) which induces oxidative stress thereby leading to various diseases like Parkinson’s disease, a example of such chemical is Bisphenol-A (BPA). BPA is a plasticizer that is widely used in the production of plastics, epoxy resin and unsaturated polystyrene. BPA is exposure in human population is due to its ubiquitous presence in food and beverages packaging. Studies have linked BPA exposure to abnormalities of reproductive system, neurodegenerative disorders amongst which are Parkinson’s disease, Alzheimer’s disease and amyotrophic lateral sclerosis. Levodopa (L-DOPA) is an amino acid that is made and used as part of normal human biology in plants and animals including humans. L-DOPA is currently used as a dopamine replacement drug in the treatment of neurobehavioral disorders associated with Parkinson’s disease. Few studied have reported antioxidant activity of L-DOPA. This study investigates the antioxidant and neuroprotective effects of L-DOPA in BPA induced toxicity in Wistar rats. Twenty adult male Wistar rats weighing between 180-250g were used in this study. the rats were randomly assigned into four groups with each group each group containing five rats (n=5). Group A was control and they were fed with rat chow and water and libitum, Group B received BPA(50mg/kg), Group C received L-DOPA(100mg/kg) and Group D were pretreated with L-DOPA (100mg/kg) 1hour before administration of BPA (50mg/kg). Administration was done orally. Experimental period lasted for 28days after which the animals were sacrificed. The results obtained showed a significant increase (p<0.05) in MDA levels in BPA treated groups. When compared with the control. This result indicates that BPA induce lipid peroxidation and oxidative stress was observed. A decrease in sod activity in rats treated with BPA only when compared with those of the control.. in rats co-treated with L-DOPA (1hr) and BPA, there was a significant improvement of sod activities in these rats. no significant difference was observed in cat levels in all treatment groups when compared with control group. there was a significant decrease (p<0.05) in GPx levels in BPA treated groups when compared to those of the control while in rats co treated with L-DOPA (1hr) and BPA, there was a significant increase in GPx activity. The result of this study showed that L-DOPA possess antioxidant properties in part due to improved SOD, CAT, GPx activities negating the oxidative stress and redox imbalance induced by BPA.
