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ABSTRACT
Diabetes mellitus (DM) is a spectrum of common metabolic disorders arising from a variety of pathologic mechanisms, all resulting in hyperglycaemia, Hyperglycaemia produces receptive oxygen species (ROS), which thus cause harm to the cells from various perspectives. Harm to the cells at last outcomes in optional confusions in diabetes mellitus. The aim of this study was to determine the activity of three oxidative markers, malondialdehyde (MDA), catalse and superoxide dismutase in streptozotocin induced diabetic rats.
Male Albino Winstar rats weighing (170 -270g) were obtained and diabetes was induced by a single dose of (40 mg/kg body weight) intraperitoneal injection of streotozotocin dissolved in freshly prepared 0.1 M citrte buffer, pH 4.5. After 48h, diabetes mellitus was confirmed (blood suger ≥ 200mg) and the animals were grouped into three groups of four rats each that included untreated diabetic group, non-diabetic group and Amlodipine plus vidagliptin group. From the study, there was significant improvement with the activities of catalse and superoxide dismutase enzymes while the assay of MDA. The addition of Amlodipine in treatment of diabetes mellitus can confer significant improvement in anti-oxidant activities.
