ABSTRACT
Due to its well-documented health advantages, Morinda citrifolia (Noni) has been widely utilized as a supplementary and alternative medicine in many nations. It has historically been used as an antibacterial, anticancer, anthelminthic, analgesic, anti-inflammatory, and immunostimulant medicinal treatment for various disorders. Additionally, it has demonstrated effectiveness in treating ailments including gastritis, skin issues, lung infections, menstruation and urinary tract problems, fever, diabetes, and venereal diseases. The present study was carried out to determine the acute toxicity properties, phytochemical constituents and anti-inflammatory properties of Morinda citrifolia seed extract using solvents of various degrees of polarity. Standard methods were used to screen the crude powdered sample of the plant seed for the presence of secondary plant metabolites and determine its median lethal dose and anti-inflammatory properties. The phytochemical analysis reveals the presence of Alkaloids, Phenols, Flavonoids, Reducing sugars, Saponins, Tannins and Steroids. The acute toxicity study shows no signs of morbidity and mortality at the following dose: 10, 100, 1000, 1600, 2900 and 5000 mg/kg. Also, Morinda citrifolia methanol extract at 200 mg/kg and n-Hexane extract at 200 mg/kg showed a significant increase in percentage inhibition compared to the negative control group and may be a good source of anti-inflammatory drugs and an alternative to NSAIDs and Steroids. The study revealed the presence of different secondary metabolites, which may be responsible for the various pharmacological activities. With a median lethal dose greater than 5000 mg/kg, it can be concluded that the aqueous extract is safe for human use when taken orally.
