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ABSTRACT
Environmental pollution remains a major concern for public health and ecosystem balance, especially when toxic substances impair essential organs like the liver and kidneys. This study examines the potential of crude extract derived from Annona muricata (soursop) phytowaste as a natural chelating agent against to lead(Pb) and Cadmium(Cd) in Wistar rats. The rats were first exposed to lead(Pb) and Cadmium(Cd) in their drinking water and then treated with different concentrations of the Annona muricata (soursop) phytowaste extract. Standard biochemical assays were employed to evaluate to lead(Pb) and Cadmium(Cd) levels and oxidative stress markers within the liver and kidneys. The results demonstrated a significant reduction in heavy metal content in the treated groups compared to the control, coupled with enhancements in antioxidant enzyme activities. Ultimately, this research highlights the promising role of plant-based chelators as cost-effective and sustainable alternatives for detoxification, and it encourages further studies to optimize dosing and explore potential applications in human health.
