PHARMACOLOGICAL EFFECT OF Irvingia gabonensis (BUSH MANGO) ON ACUTE AND SUB-ACUTE INFLAMMATIONS INDUCED IN SWISS ALBINO MICE .

ABSTRACT

Irvingia gabonensis (Bush Mango) is a species of African trees in the genus Irvingia, sometimes known by the common names Wild mango, African mango, or bush mango. This study was aimed to investigate the effect of the ethanol extract of Irvingia gabonensis leaves (EEIG) in the treatment of inflammations induced in albino rats. The phytochemical assay, acute toxicity and anti-inflammatory studies of the ethanol extract of Irvingia gabonenesis leaves (EEIG) (acute and chronic induced inflammations) in albino rats were carried out using standard procedures. Results of phytochemical tests of ethanol extract of Irvingia gabonensis leaves (EEIG) showed the presence of glycosides, carbohydrates, saponins, flavonoid, phenolics, eugenols, terpenes, reducing sugar alkaloid, steroid and tannin. Results from the acute toxicity study revealed that the LD₅₀ was more than 1000mg/kg. The anti-inflammatory study revealed dose dependent anti-inflammatory activity of the extract in both acute and chronic induced inflammations. It is concluded that the ethanol extract of Irvingia gabonensis leaves 9EEIG), displayed anti-inflammatory activity and should be tried clinically on patients with arthritis and inflammations.