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ABSTRACT
The world's oldest system of health care is the application of herbal medicine and has been used in all cultures. Up to 10% of people worldwide are affected by the chronic condition known as inflammation and arthritis. Arthritis basically means inflammation of the joints. All conditions that have an impact on the joints are commonly referred to as having arthritis. These illnesses are included in the larger category of rheumatic diseases. Arthritic pain is likely the most well-known type of pain in both primary and secondary care. When joints become inflamed, they can cause stiffness, warmth, swelling, redness, and discomfort. Gout, rheumatoid arthritis, osteoarthritis, psoriatic arthritis, lupus, and spondylitis are only a few of the many kinds of arthritis. This study was aim to investigate the acute toxicity and effect of the ethanol extract of Curcuma longa (Turmeric rhizome) in the treatment of inflammations induced in albino rats. The acute toxicity effect and anti-inflammatory studies of the ethanol extract of Curcuma longa (Turmeric rhizome) (acute and chronic induced inflammations) in albino rats were carried out using standard procedures. Results from the acute toxicity study revealed that the LD50 was more than 5000 mg/kg. The anti-inflammatory study revealed dose dependent anti-inflammatory activity of the extract in both acute and chronic induced inflammations. It is concluded that the ethanol extract of Curcuma longa (Turmeric rhizome), displayed anti-inflammatory activity and should be tried clinically on patients with arthritis and inflammations.
