PATHOLOGIC EFFECTS OF PROPHYLACTIC ABUSE OF CINCHONA OFFICINALIS DERIVATIVES

ABSTRACT

Since the advent of COVID-19 pandemic in which the world was thrown into pandemonium on the way forward with new variant surfacing every other day. Health practitioners world-wide are increasingly getting overwhelmed while at a time there was a complete breakdown of major hospital work forces in most countries (Odigie et al., 2020a). Despite the devastation globally, selfmedication or personal intervention should never be encouraged because it often results to liver damage (Odigie et al., 2020b). Self-medication or personal intervention is a precursor to drug abuse, which has been reported as one of the leading causes of liver damage globally (Atoigwe et al., 2016). The liver is prone to xenobiotics-induced injury because of its central role in xenobiotic metabolism and its portal location within the circulatory system (Adesanya et al., 2012; Odigie and Odigie, 2015). Many drugs and chemicals have adverse effects on the liver and lead to distortion of liver architecture (Olurishe et al., 2011). Therefore, the liver must be protected being at the receiving end while trying to metabolize drugs in its abused state (Odigie and Obaseki, 2015).