ABSTRACT

Monosodium glutamate (MSG) has been associated with several adverse effects, including its toxicity on reproductive organs. Vitamin E, a well-known antioxidant, is widely used to protect various organs against oxidative damage. The aim of this study was to investigate the protective potential of vitamin E against MSG-induced ovariotoxicity in adult Wistar rats. Twenty (20) adult female Wistar rats weighing between 170g and 200g were randomly divided into four (4) groups, each containing a total of five (5) rats: Group A served as the control, Group B was administered 200 mg/kg body weight of monosodium glutamate orally for 28 days, Group C was administered 100 IU/kg body weight of vitamin E following treatment with 200 mg/kg body weight of monosodium glutamate orally for 28 days, and Group D was administered 100 IU/kg body weight of vitamin E only, orally for 28 days. Histological findings revealed alterations, including a reduced number of developing follicles, an increased number of atretic follicles and increased accumulation of collagen fibers (fibrosis). However, co-administration of vitamin E with monosodium glutamate mitigated the adverse effects associated with excessive MSG consumption, thereby demonstrating its protective role against MSG toxicity. In conclusion, this study provides histological evidence demonstrating that vitamin E safeguards the ovary from damage induced by monosodium glutamate.