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A three–variable Box–Behnken design (BBD) in combination with response surface methodology (RSM) was utilized to optimize and evaluate the effect of adsorbent dose, contact time and pH level on percentage reduction of BOD, COD and TDS in brewery effluent. Adsorbent was prepared from coconut shell, which was carbonized at temperature of 500oC for 1 hour and thereafter activated. The effluent was treated with the adsorbent by varying three variables: adsorbent dosage(1–5 g), contact time (40–180) and pH
(2–8). Statistical analysis of the results showed that all the factors, except the contact time, had least significant effect on the responses of Linear and Quadratic models were developed for percentage reduction of (biological oxygen demand) BOD, chemical oxygen demand (COD) and total dissolved solids (TDS). The models were significant with p < 0.0001 and showed a good fit to the experimental data. The percentage reduction of BOD, COD and TDS were positively influenced by adsorbent dose and contact time. The contact time range used for this study did not have so much effect on the responses. The optimum conditions for BOD, COD and TDS reduction of 81.7%, 83.8% and 94.2% respectively were adsorbent dosage of 5g, contact time of 102.41 minutes and pH of 8.